Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425114 | 0.89 | CYP1A2 (0.44) | ROCK2PRKCZPRKD2HRH3GPR6 | |
| SCHEMBL2424276 | 0.89 | PRKCZ (0.45) | ROCK2PRKCZPRKD2GPR6CYP1A2 | |
| SCHEMBL13087402 | 0.86 | ROCK2 (0.42) | ROCK2PRKCZPRKD2HRH3MAP4K1 | |
| SCHEMBL2430099 | 0.85 | IRAK4 (0.45) | ROCK2IRAK4CLK4 | |
| SCHEMBL3628367 | 0.85 | ROCK2 (0.47) | ROCK2PRKCZPRKD2MAP4K1GPR6 | |
| SCHEMBL2427707 | 0.83 | ROCK2 (0.49) | ROCK2PRKCZPRKD2GPR6ROCK1 | |
| SCHEMBL2425647 | 0.83 | ROCK2 (0.43) | ROCK2PRKCZPRKD2GPR6IRAK4 | |
| SCHEMBL2424533 | 0.83 | ROCK2 (0.43) | ROCK2PRKCZPRKD2GPR6IRAK4 | |
| SCHEMBL2422015 | 0.83 | ROCK2 (0.49) | ROCK2PRKCZPRKD2GPR6ROCK1 | |
| SCHEMBL13087712 | 0.82 | ROCK2 (0.45) | ROCK2PRKCZPRKD2GPR6ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-B1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2013-08-07 | — | — | EP | disclosed |
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | RELA, NFKBIA, NFKB2 | ROCK2 1065/4885PRKCZ 272/4885PRKD2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.