Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629011 | 0.86 | GBA1 (0.44) | GBA1ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3092937 | 0.82 | PIK3CA (0.47) | GBA1ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3629695 | 0.79 | MAPT (0.44) | GBA1ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3627322 | 0.77 | F10 (0.39) | GBA1PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL3630265 | 0.77 | F10 (0.37) | GBA1ALDH1A1MAPTSMN1; SMN2HSD11B1 | |
| SCHEMBL3635713 | 0.76 | HCRTR1 (0.51) | GBA1ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3633555 | 0.73 | SLC6A7 (0.44) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3634324 | 0.72 | PIK3CA (0.43) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3098002 | 0.72 | PIK3CB (0.49) | GBA1ALDH1A1MAPTSMN1; SMN2PIK3CD | |
| SCHEMBL3630355 | 0.72 | PIK3CB (0.39) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |