SCHEMBL3628513

SCHEMBL3628513

Nc1cccc(N2C(=O)c3ccc4c5ccc6c7c(ccc(c8ccc(c3c48)C2=O)c75)C(=O)N(c2cccc(N)c2)C6=O)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.71
MEN1 O00255 6/20 0.71
USP2 O75604 5/20 0.71
KEAP1 Q14145 3/20 0.71
NFE2L2 Q16236 3/20 0.71
NPC1 O15118 3/20 0.57
RAB9A P51151 3/20 0.57
L3MBTL1 Q9Y468 3/20 0.52
ALDH1A1 P00352 7/20 0.51
KDM4E B2RXH2 4/20 0.51
MAPT P10636 2/20 0.51
HTT P42858 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
POLB P06746 3/20 0.48
TSHR P16473 2/20 0.44
CASP1 P29466 2/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ESR1 P03372 1/20 0.44
CASP7 P55210 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601803 0.87 KMT2A (0.56) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL9566664 0.81 NPC1 (0.65) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL13910988 0.81 KMT2A (0.67) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL16601773 0.81 NPC1 (0.87) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL14268808 0.81 NPC1 (0.57) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL16601675 0.80 KMT2A (0.58) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL18347274 0.80 POLB (0.56) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL7597251 0.79 ALDH1A1 (0.60) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL29726032 0.79 ALDH1A1 (0.60) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL1127945 0.79 ALDH1A1 (0.60) KMT2AMEN1USP2KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
EP-2248912-B1 High sensitivity assays for pathogen detection using metal-enhanced fluorescence UNIV MARYLAND BIOTECHNOLOGY (US) 2013-03-06 EP disclosed
EP-2248912-A1 High sensitivity assays for pathogen detection using metal-enhanced fluorescence University of Maryland Biotechnology (US) 2010-11-10 EP disclosed
US-5077161-A Imaging members with bichromophoric bisazo perylene photoconductive materials XEROX CORPORATION (US) 1991-12-31 US disclosed