SCHEMBL3628834

SCHEMBL3628834

O=C(O)[C@](S)(c1ccccc1Cl)N1CCc2sccc2C1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 3/20 0.44
CYP2C19 P33261 3/20 0.44
DRD1 P21728 3/20 0.44
ADRA2A P08913 2/20 0.44
CYP2B6 P20813 2/20 0.44
OPRM1 P35372 2/20 0.44
OPRK1 P41145 2/20 0.44
HTR2B P41595 2/20 0.44
KCNH2 Q12809 2/20 0.44
ALDH1A1 P00352 2/20 0.44
DRD4 P21917 2/20 0.44
DRD3 P35462 2/20 0.44
USP2 O75604 1/20 0.44
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
ADRB3 P13945 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1986102 0.86 ABCB11 (0.46) ABCB11CYP2C19DRD1ADRA2ACYP2B6
SCHEMBL954553 0.84 DRD1 (0.47) ABCB11CYP2C19DRD1ADRA2ACYP2B6
SCHEMBL1269320 0.84 DRD1 (0.47) ABCB11CYP2C19DRD1ADRA2ACYP2B6
Hydrochloric Acid SCHEMBL3077710 0.83 DRD1 (0.46) ABCB11CYP2C19DRD1ADRA2ACYP2B6
Bromide SCHEMBL2087060 0.83 DRD1 (0.46) ABCB11CYP2C19DRD1ADRA2ACYP2B6
Hydrochloric Acid SCHEMBL3077705 0.83 DRD1 (0.46) ABCB11CYP2C19DRD1ADRA2ACYP2B6
Hydrochloric Acid SCHEMBL6615615 0.82 DRD1 (0.45) ABCB11CYP2C19DRD1ADRA2ACYP2B6
SCHEMBL5028770 0.81 ABCB11 (0.46) ABCB11CYP2C19DRD1ADRA2ACYP2B6
SCHEMBL6208238 0.81 ABCB11 (0.42) ABCB11CYP2C19DRD1ADRA2ACYP2B6
Sulfuric Acid SCHEMBL6363639 0.80 ABCB11 (0.50) ABCB11CYP2C19DRD1ADRA2ACYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024114797-A1 SOLID PREPARATION CONTAINING OXIDIZED CLOPIDOGREL AND PREPARATION METHOD THEREFOR 成都施贝康生物医药科技有限公司 2024-06-06 WO disclosed
WO-2023241688-A1 PHARMACEUTICAL COMPOSITION FOR TREATING AND RESISTING BLOOD COAGULATION AND USE THEREOF 成都施贝康生物医药科技有限公司 2023-12-21 WO disclosed
CN-116947743-A Nitrosothiol compound and synthesis method and application thereof 南京雷正医药科技有限公司 2023-10-27 CN disclosed
EP-3766493-B1 METHOD FOR IMPROVING THE STABILITY OF CLOPIDOGREL USING SULFOALKYL ETHER CYCLODEXTRIN CYDEX PHARMACEUTICALS INC (US) 2023-08-23 EP disclosed
CN-116262116-A Solid preparation containing clopidogrel oxide and preparation method thereof 成都施贝康生物医药科技有限公司 2023-06-16 CN disclosed
CN-115518066-A Pharmaceutical composition for treating anticoagulation and application 成都施贝康生物医药科技有限公司 2022-12-27 CN disclosed
EP-3766493-A1 METHOD FOR IMPROVING THE STABILITY OF CLOPIDOGREL USING SULFOALKYL ETHER CYCLODEXTRIN CyDex Pharmaceuticals, Inc. (US) 2021-01-20 EP disclosed
EP-2152078-B1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CYDEX PHARMACEUTICALS INC (US) 2021-01-13 EP disclosed
US-10512697-B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYDEX PHARMACEUTICALS, INC. (US) 2019-12-24 US disclosed
CN-104800210-B Preparation comprising clopidogrel and sulfoalkyl ether cyclodextrin and its application method 锡德克斯药物公司 2019-08-06 CN disclosed
US-9125945-B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYDEX PHARMACEUTICALS, INC. (US) 2015-09-08 US disclosed
CN-104800210-A Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYDEX PHARMACEUTICALS INC 2015-07-29 CN disclosed
CN-101686681-B Formulations comprising clopidogrel and sulfoalkyl ether cyclodextrins and methods of use thereof CYDEX PHARMACEUTICALS INC 2015-04-01 CN disclosed
US-20150025243-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-01-22 US disclosed
US-8853236-B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYDEX PHARMACEUTICALS, INC. (US) 2014-10-07 US disclosed
US-20130129700-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CYDEX PHARMACEUTICALS, INC. (US) 2013-05-23 US disclosed
US-8343995-B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYDEX PHARMACEUTICALS, INC. (US) 2013-01-01 US disclosed
US-20100292268-A1 Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use CYDEX PHARMACEUTICALS, INC. (US) 2010-11-18 US disclosed
EP-2152078-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CyDex Pharmaceuticals, Inc. (US) 2010-02-17 EP disclosed
WO-2008134600-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CYDEX PHARMACEUTICALS, INC. (US) 2008-11-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025243-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CYP2C19, CYP2C9, CYP3A7 ABCB11 114/4885CYP2C19 1/4885DRD1 687/4885
US-10512697-B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use CYP2C19, CYP2C9, CYP3A7 ABCB11 114/4885CYP2C19 1/4885DRD1 687/4885
US-20130129700-A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE CYP2C19, CYP2C9, CYP3A7 ABCB11 114/4885CYP2C19 1/4885DRD1 687/4885
US-20100292268-A1 Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use CYP2C19, CYP2C9, CYP3A7 ABCB11 114/4885CYP2C19 1/4885DRD1 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.