Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628880 | 1.00 | NT5E (0.44) | NT5EL3MBTL1MAPTCCR1CCR8 | |
| SCHEMBL1258312 | 0.85 | KCNH2 (0.47) | NT5EL3MBTL1CYP2D6KCNH2ADORA2A | |
| SCHEMBL2710931 | 0.84 | NT5E (0.48) | NT5EL3MBTL1MAPTCCR1CCR8 | |
| SCHEMBL9493460 | 0.82 | NT5E (0.43) | NT5EL3MBTL1CCR1CCR8NPSR1 | |
| SCHEMBL2711028 | 0.81 | NT5E (0.49) | NT5EL3MBTL1MAPTCCR1CCR8 | |
| SCHEMBL3631708 | 0.80 | ENPP1 (0.56) | NT5EL3MBTL1MAPTCCR1CCR8 | |
| SCHEMBL2711191 | 0.80 | ELANE (0.48) | NT5EL3MBTL1MAPTCRHR1NPSR1 | |
| SCHEMBL9494064 | 0.78 | NT5E (0.43) | NT5EL3MBTL1CCR1CCR8NPSR1 | |
| SCHEMBL1452285 | 0.76 | NT5E (0.45) | NT5EL3MBTL1CCR1CCR8NPSR1 | |
| SCHEMBL874733 | 0.76 | NQO2 (0.48) | ADORA2AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781586-B2 | Metathesis catalysts | HOFFMAN-LA ROCHE INC. (US) | 2010-08-24 | — | — | US | disclosed |
| EP-2044095-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METAHESIS REACTIONS | F. Hoffmann-Roche AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| US-20080021219-A1 | Metathesis Catalysts | HOFFMANN-LA ROCHE INC. | 2008-01-24 | — | — | US | disclosed |
| WO-2008000644-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METAHESIS REACTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021219-A1 | Metathesis Catalysts | MTX1, MTX2, MLX | NT5E 4126/4885L3MBTL1 332/4885MAPT 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.