Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HAT1 | O14929 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644277 | 0.87 | ALDH1A1 (0.83) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL10253551 | 0.87 | ALDH1A1 (0.83) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL2133676 | 0.84 | MEN1 (0.65) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL29644278 | 0.84 | MEN1 (0.65) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL16203495 | 0.84 | ALDH1A1 (0.54) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL1557638 | 0.83 | MEN1 (0.68) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL11773319 | 0.82 | MEN1 (0.62) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL3174159 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL9936837 | 0.81 | NR4A2 (0.65) | ALDH1A1MEN1CYP1A2HPGDALOX12 | |
| SCHEMBL2978109 | 0.79 | CYP1A2 (1.00) | ALDH1A1MEN1CYP1A2HPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | claimed |
| CN-116867768-A | STING antagonists and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2023-10-10 | — | — | CN | disclosed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |