Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 6/20 | 0.50 |
| ▸ | CD74 | P04233 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629990 | 0.85 | IDO1 (0.52) | TNIKPOLBMIFCD74MEN1 | |
| SCHEMBL2548789 | 0.83 | MIF (0.52) | TNIKPOLBMIFCD74MEN1 | |
| SCHEMBL3632389 | 0.82 | MIF (0.47) | TNIKPOLBMIFCD74BRAF | |
| SCHEMBL2547710 | 0.78 | MIF (0.75) | TNIKPOLBMIFCD74MEN1 | |
| SCHEMBL3627242 | 0.78 | MIF (0.53) | POLBMIFCD74MEN1KMT2A | |
| SCHEMBL2548545 | 0.76 | IDO1 (0.59) | TNIKPOLBMIFCD74MEN1 | |
| SCHEMBL28782675 | 0.76 | IDO1 (0.53) | TNIKPOLBMIFCD74PLA2G2A | |
| SCHEMBL14563237 | 0.75 | MIF (0.60) | TNIKPOLBMIFCD74 | |
| SCHEMBL13981971 | 0.73 | SIGMAR1 (0.48) | TNIKPOLBMIFKMT2ANPC1 | |
| SCHEMBL3633664 | 0.73 | MIF (0.48) | TNIKPOLBMIFCD74BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |
| EP-2150551-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |