Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526377 | 0.81 | MEN1 (0.45) | KMT2AMEN1ALDH1A1NPSR1TSHR | |
| SCHEMBL24124378 | 0.80 | NPSR1 (0.36) | KMT2AMEN1ALDH1A1NPSR1HTT | |
| SCHEMBL31043942 | 0.80 | MEN1 (0.35) | KMT2AMEN1ALDH1A1NPSR1HTT | |
| SCHEMBL2849063 | 0.77 | MEN1 (0.50) | KMT2AMEN1ALDH1A1NPSR1TSHR | |
| SCHEMBL9512535 | 0.75 | ALDH1A1 (0.42) | KMT2AALDH1A1NPSR1HTTTSHR | |
| SCHEMBL6058712 | 0.74 | MEN1 (0.59) | KMT2AMEN1ALDH1A1NPSR1TSHR | |
| SCHEMBL3079757 | 0.74 | ALDH1A1 (0.41) | KMT2AALDH1A1NPSR1HTTTSHR | |
| SCHEMBL28417551 | 0.74 | ALDH1A1 (0.41) | KMT2AALDH1A1NPSR1HTTLMNA | |
| SCHEMBL218350 | 0.72 | ALDH1A1 (0.40) | KMT2AALDH1A1NPSR1HTTTSHR | |
| SCHEMBL15515009 | 0.72 | ALDH1A1 (0.40) | KMT2AALDH1A1NPSR1HTTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829487-B2 | Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| US-20190194192-A1 | NOVEL BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
| EP-2242776-A1 | MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS | BASF Corporation (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009088596-A1 | MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS | BASF CATALYSTS LLC (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194192-A1 | NOVEL BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS | SOS1, SOST, SOS2 | KMT2A 3605/4885MEN1 201/4885ALDH1A1 1511/4885 |
| US-10829487-B2 | Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors | SOS1, SOST, BMP1 | KMT2A 3027/4885MEN1 115/4885ALDH1A1 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.