Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631614 | 0.86 | LMNA (0.37) | HRH3KCNH2MEN1POLBKMT2A | |
| SCHEMBL3628240 | 0.79 | ALDH1A1 (0.34) | HRH3KCNH2KDM4ESLC2A1 | |
| SCHEMBL3322215 | 0.77 | SLC2A1 (0.51) | HRH3KDM4EMAPK1HSD17B10MEN1 | |
| SCHEMBL3326154 | 0.75 | LMNA (0.42) | HRH3KCNH2KDM4EMAPK1HSD17B10 | |
| SCHEMBL3633564 | 0.68 | CYP2C9 (0.45) | — | |
| SCHEMBL13499969 | 0.66 | LMNA (0.58) | HRH3KDM4E | |
| SCHEMBL3320403 | 0.64 | CACNA2D1 (0.43) | HRH3KCNH2MAOB | |
| SCHEMBL3633491 | 0.63 | LPAR2 (0.43) | KDM4EPOLB | |
| SCHEMBL3321755 | 0.63 | HRH3 (0.47) | HRH3KDM4EHSD17B10 | |
| SCHEMBL3322417 | 0.62 | HRH3 (0.49) | HRH3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155748-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-02-24 | — | — | EP | claimed |
| WO-2008144268-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-27 | — | — | WO | claimed |
| EP-2155748-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008144268-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-27 | — | — | WO | disclosed |