Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31318376 | 1.00 | HSD17B10 (0.60) | HSD17B10RORCKMT2AALDH1A1POLB | |
| SCHEMBL6050849 | 0.86 | HSD17B10 (0.56) | HSD17B10RORCKMT2AALDH1A1POLB | |
| SCHEMBL29563911 | 0.85 | HSD17B10 (0.60) | HSD17B10RORCKMT2AALDH1A1POLB | |
| SCHEMBL1148427 | 0.85 | HSD17B10 (0.60) | HSD17B10RORCKMT2AALDH1A1POLB | |
| Selenium SCHEMBL10605380 | 0.84 | HSD17B10 (0.58) | HSD17B10RORCKMT2AALDH1A1POLB | |
| SCHEMBL11300569 | 0.83 | HSD17B10 (0.62) | HSD17B10KMT2AALDH1A1HIF1APDE7A | |
| SCHEMBL1999857 | 0.82 | PDE7A (0.54) | HSD17B10KMT2AALDH1A1POLBHIF1A | |
| SCHEMBL4641866 | 0.81 | HSD17B10 (0.60) | HSD17B10KMT2AALDH1A1PDE7AVCAM1 | |
| SCHEMBL27775732 | 0.80 | HSD17B10 (0.58) | HSD17B10KMT2AALDH1A1HIF1APDE7A | |
| SCHEMBL30619304 | 0.79 | ALDH1A1 (0.53) | HSD17B10RORCKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962890-B1 | Multifunctional crosslinkers for shape-memory polyimides, polyamides and poly(amide-imides) and methods of making the same | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2015-02-24 | — | — | US | claimed |
| CN-100368383-C | Fluorine containing asymmetric aromatic ether diamine and preparation and use thereof | UNIV LANZHOU (CN) | 2008-02-13 | — | — | CN | claimed |
| CN-1821215-A | Fluorine containing asymmetric aromatic ether diamine and preparation and use thereof | UNIV LANZHOU (CN) | 2006-08-23 | — | — | CN | claimed |
| US-10584110-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20180208575-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA L.P. | 2018-07-26 | — | — | US | disclosed |
| US-9878991-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160355499-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA L.P. | 2016-12-08 | — | — | US | disclosed |
| US-9365563-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2604598-B1 | TRPV1 antagonists and uses thereof | PURDUE PHARMA LP (US) | 2016-04-06 | — | — | EP | disclosed |
| US-8962890-B1 | Multifunctional crosslinkers for shape-memory polyimides, polyamides and poly(amide-imides) and methods of making the same | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962890-B1 | Multifunctional crosslinkers for shape-memory polyimides, polyamides and poly(amide-imides) and methods of making the same | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2000034269-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |
| WO-2000034260-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |
| EP-0272728-B1 | PROCESS FOR THE PREPARATION OF POLYMERS OF C0 AND OLEFINICALLY UNSATURATED COMPOUNDS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1993-04-07 | — | — | EP | disclosed |
| EP-0272728-A2 | Process for the preparation of polymers of C0 and olefinically unsaturated compounds | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-06-29 | — | — | EP | disclosed |
| US-4224340-A | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds | WILLIAM H. RORER, INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4214003-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1980-07-22 | — | — | US | disclosed |
| US-4197314-A | WITH A DIPHENYL NITRONE | WILLIAM H. RORER, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4181519-A | Diphenylamine derivative herbicides | SHELL OIL COMPANY (US) | 1980-01-01 | — | — | US | disclosed |
| US-4153722-A | ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE | WILLIAM H. RORER, INC. (US) | 1979-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208575-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | TRPV1, TRPA1, TRPV5 | HSD17B10 2157/4885RORC 434/4885KMT2A 4058/4885 |
| US-20160355499-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | TRPV1, TRPA1, TRPV5 | HSD17B10 2157/4885RORC 434/4885KMT2A 4058/4885 |
| US-10584110-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | TRPV1, TRPA1, TRPV5 | HSD17B10 2157/4885RORC 434/4885KMT2A 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.