Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630704 | 1.00 | ACHE (0.47) | ACHEIRAK4ARFERCHUK | |
| SCHEMBL3624947 | 0.88 | ACHE (0.46) | ACHEIRAK4KMT2A | |
| SCHEMBL3624945 | 0.88 | ACHE (0.46) | ACHEIRAK4KMT2A | |
| SCHEMBL1937156 | 0.80 | ACHE (0.41) | ACHEIRAK4BCHEGPR6BCL6 | |
| SCHEMBL1937158 | 0.80 | ACHE (0.41) | ACHEIRAK4BCHEGPR6BCL6 | |
| SCHEMBL3627940 | 0.79 | GPR65 (0.40) | ACHEARKMT2ARXFP1ALDH1A1 | |
| SCHEMBL3627945 | 0.79 | GPR65 (0.40) | ACHEARKMT2ARXFP1ALDH1A1 | |
| SCHEMBL3631179 | 0.78 | IRAK4 (0.56) | IRAK4GPR6 | |
| SCHEMBL3631182 | 0.78 | IRAK4 (0.56) | IRAK4GPR6 | |
| SCHEMBL27169503 | 0.74 | HDAC8 (0.53) | ARKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |