Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624945 | 1.00 | ACHE (0.46) | ACHEKHKPDE4BPDE4DPDE4A | |
| SCHEMBL17498356 | 0.89 | KHK (0.51) | ACHEKHKROCK2ROCK1IRAK4 | |
| SCHEMBL3630702 | 0.88 | ACHE (0.47) | ACHEIRAK4KMT2A | |
| SCHEMBL3630704 | 0.88 | ACHE (0.47) | ACHEIRAK4KMT2A | |
| SCHEMBL3630458 | 0.85 | KDM4E (0.41) | ACHEPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3630454 | 0.85 | KDM4E (0.41) | ACHEPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL9107040 | 0.85 | KHK (0.41) | ACHEKHK | |
| SCHEMBL14911459 | 0.85 | KHK (0.41) | ACHEKHK | |
| SCHEMBL2713345 | 0.85 | KHK (0.41) | ACHEKHK | |
| SCHEMBL3628370 | 0.83 | ROCK2 (0.53) | PDE4BPDE4DPDE4APDE4CROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |