Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.41 |
| ▸ | EDNRA | P25101 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635425 | 0.83 | HPGD (0.42) | EDNRBEDNRAALDH1A1HSD17B10USP2 | |
| SCHEMBL3938675 | 0.81 | HSD17B10 (0.47) | EDNRBEDNRAALDH1A1HSD17B10USP2 | |
| SCHEMBL3636997 | 0.75 | ALDH1A1 (0.51) | ALDH1A1HSD17B10USP2HPGDKDM4E | |
| SCHEMBL848167 | 0.72 | EDNRA (0.60) | EDNRBEDNRAMAPTPOLB | |
| SCHEMBL847742 | 0.70 | MAPK8 (0.59) | EDNRA | |
| SCHEMBL9281684 | 0.70 | HTT (0.59) | ALDH1A1HSD17B10USP2HPGDKDM4E | |
| SCHEMBL3637957 | 0.69 | MAPK8 (0.45) | KDM4E | |
| SCHEMBL847034 | 0.68 | SMN1; SMN2 (0.52) | EDNRBEDNRAALDH1A1HSD17B10USP2 | |
| SCHEMBL848642 | 0.68 | MAPK8 (0.59) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL3636491 | 0.67 | TP53 (0.40) | ALDH1A1HSD17B10USP2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |