Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630797 | 0.83 | EDNRB (0.41) | HPGDALDH1A1EDNRBKMT2AMEN1 | |
| SCHEMBL3938675 | 0.82 | HSD17B10 (0.47) | HPGDALDH1A1MAPK1EDNRBKMT2A | |
| SCHEMBL3636491 | 0.81 | TP53 (0.40) | HPGDALDH1A1MAPK1USP2HSD17B10 | |
| SCHEMBL3636997 | 0.77 | ALDH1A1 (0.51) | HPGDALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL3637957 | 0.74 | MAPK8 (0.45) | KDM4E | |
| SCHEMBL14604587 | 0.74 | LMNA (0.44) | HPGDALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL3634026 | 0.73 | MAPK8 (0.44) | KMT2AMEN1 | |
| SCHEMBL3634689 | 0.73 | MAPK8 (0.42) | ALDH1A1KMT2AMEN1USP2HSD17B10 | |
| SCHEMBL3631272 | 0.72 | MAPK8 (0.44) | ALDH1A1KMT2AMEN1USP2HSD17B10 | |
| SCHEMBL14604214 | 0.72 | MAPK8 (0.51) | ALDH1A1KMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |