Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31255580 | 0.98 | LMNA (0.32) | LMNAHSD17B10SLC6A4SLC6A3ATM | |
| SCHEMBL19063653 | 0.88 | KDM4E (0.33) | SLC6A4SLC6A3ATMCSNK2A2CSNK2A1 | |
| SCHEMBL17076623 | 0.84 | ALOX5 (0.35) | LMNAHSD17B10ATMCSNK2A2CSNK2A1 | |
| SCHEMBL3619346 | 0.84 | SSTR4 (0.30) | LMNAHSD17B10 | |
| SCHEMBL1711675 | 0.84 | CPN1 (0.35) | LMNAHSD17B10SLC6A4SLC6A3CSNK2A2 | |
| SCHEMBL29560810 | 0.78 | CHRNB2 (0.34) | HSD17B10SLC6A4SLC6A3 | |
| SCHEMBL28722096 | 0.75 | CSNK2A2 (0.37) | ATMCSNK2A2CSNK2A1 | |
| SCHEMBL3465229 | 0.74 | SLC6A2 (0.36) | SLC6A4SLC6A3 | |
| SCHEMBL29239448 | 0.74 | — | — | |
| SCHEMBL16338060 | 0.74 | ALOX5 (0.33) | CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110896634-A | 2- (4-chlorophenoxy) -N- ((1- (2- (4-chlorophenoxy) ethynylazetidin-3-yl) methyl) acetamide derivatives and related compounds as ATF4 inhibitors for the treatment of cancer and other diseases | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-03-20 | — | — | CN | disclosed |
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |