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Sugi Predict / Compounds / Mosapride

Mosapride

Mosapride

SCHEMBL3630976

[2H]c1c(F)ccc(C([2H])([2H])N2CCOC(C([2H])([2H])NC(=O)c3cc(Cl)c(N)cc3OCC)C2)c1[2H]

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HTR3AHTR3BHTR3CHTR3DHTR3EHTR4

The experimentally established mechanism targets of Mosapride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR4 known ✓ Q13639 4/20 0.45
▸ HTR3E known ✓ A5X5Y0 1/20 0.39
▸ HTR3B known ✓ O95264 1/20 0.39
▸ HTR3A known ✓ P46098 1/20 0.39
▸ HTR3D known ✓ Q70Z44 1/20 0.39
▸ HTR3C known ✓ Q8WXA8 1/20 0.39
▸ CYP3A4 P08684 4/20 0.70
▸ KCNH2 Q12809 4/20 0.70
▸ DRD3 P35462 4/20 0.70
▸ CYP2C9 P11712 3/20 0.70
▸ CYP1A2 P05177 2/20 0.70
▸ HTR1A P08908 2/20 0.70
▸ ADRA2A P08913 2/20 0.70
▸ ADRA2B P18089 2/20 0.70
▸ HTR2C P28335 2/20 0.70
▸ SLC6A4 P31645 2/20 0.70
▸ CYP2C19 P33261 2/20 0.70
▸ HTR2B P41595 2/20 0.70
▸ SIGMAR1 Q99720 2/20 0.70
▸ MEN1 O00255 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mosapride SCHEMBL3633487 0.90 DRD3 (0.85) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL13840049 0.89 DRD3 (0.75) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL29400580 0.82 DRD3 (1.00) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL16417 0.82 DRD3 (1.00) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL6228981 0.82 DRD3 (1.00) CYP3A4KCNH2DRD3CYP2C9CYP1A2
SCHEMBL13840025 0.82 DRD3 (0.69) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL6225436 0.82 DRD3 (0.98) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL6227991 0.82 DRD3 (0.98) CYP3A4KCNH2DRD3CYP2C9CYP1A2
Mosapride SCHEMBL2369236 0.82 DRD3 (0.98) CYP3A4KCNH2DRD3CYP2C9CYP1A2
SCHEMBL13840026 0.81 KCNH2 (0.75) CYP3A4KCNH2DRD3CYP2C9CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2148867-B1 DEUTERATED MORPHOLINYL COMPOUNDS CONCERT PHARMACEUTICALS INC (US) 2014-09-10 — — EP disclosed
EP-2148867-A1 DEUTERATED MORPHOLINYL COMPOUNDS Concert Pharmaceuticals Inc. (US) 2010-02-03 — — EP disclosed
US-7528131-B2 Substituted morpholinyl compounds CONCERT PHARMACEUTICALS INC. (US) 2009-05-05 — — US disclosed
WO-2008131259-A1 DEUTERATED MORPHOLINYL COMPOUNDS CONCERT PHARMACEUTICALS INC. (US) 2008-10-30 — — WO disclosed
US-20080261983-A1 Substituted morpholinyl compounds CONCERT PHARMACEUTICALS INC. (US) 2008-10-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080261983-A1 Substituted morpholinyl compounds HTR4, SLC6A4, HTR3B HTR4 1/4885HTR3E 16/4885HTR3B 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.