Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519629 | 1.00 | MAPT (0.54) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL4768330 | 0.85 | NPSR1 (0.48) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL7743403 | 0.81 | KMT2A (0.44) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL10877147 | 0.79 | MAPT (0.79) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL842766 | 0.79 | MAPT (0.60) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL842765 | 0.79 | MAPT (0.60) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL14577510 | 0.79 | MAPT (0.60) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL20590123 | 0.78 | EPHX2 (0.45) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10805796 | 0.78 | EPHX2 (0.45) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1022149 | 0.78 | RAB9A (0.59) | MAPTALDH1A1LMNATHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150534-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | disclosed |