Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8583041 | 0.87 | LMNA (0.61) | LMNADRD3DRD2TDP1HDAC4 | |
| Ethylene SCHEMBL8582548 | 0.86 | LMNA (0.60) | LMNADRD3DRD2TDP1HDAC4 | |
| Fumaric Acid SCHEMBL10826414 | 0.84 | ALDH1A1 (0.56) | LMNADRD3DRD2TDP1HDAC4 | |
| Fumaric Acid SCHEMBL10826412 | 0.84 | ALDH1A1 (0.56) | LMNADRD3DRD2TDP1HDAC4 | |
| SCHEMBL9178958 | 0.82 | DRD3 (0.72) | DRD3DRD2TDP1HRH1SLC6A2 | |
| SCHEMBL7386077 | 0.81 | DRD3 (0.65) | LMNADRD3DRD2TDP1ALDH1A1 | |
| SCHEMBL6618656 | 0.81 | DRD3 (0.63) | LMNADRD3DRD2TDP1OPRM1 | |
| Hydrochloric Acid SCHEMBL30473057 | 0.81 | HRH1 (0.73) | DRD3DRD2TDP1HRH1SLC6A2 | |
| SCHEMBL8582550 | 0.81 | OPRD1 (0.56) | LMNADRD3DRD2TDP1HDAC4 | |
| SCHEMBL28066404 | 0.80 | TSHR (0.63) | LMNADRD3DRD2ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487444-B9 | USE OF PYRIDYL AMIDES AS INHIBITORS OF ANGIOGENESIS | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-07-21 | — | — | EP | claimed |
| EP-1487444-B1 | USE OF PYRIDYL AMIDES AS INHIBITORS OF ANGIOGENESIS | ASTELLAS DEUTSCHLAND GMBH (DE) | 2009-12-30 | — | — | EP | claimed |