Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365450 | 0.86 | WNT3A (0.43) | TLR9TLR7TLR8PROKR1 | |
| SCHEMBL363251 | 0.82 | KCNH2 (0.33) | — | |
| SCHEMBL370939 | 0.82 | KCNH2 (0.33) | — | |
| SCHEMBL370168 | 0.82 | CYP19A1 (0.33) | PROKR1MAPKAPK2 | |
| SCHEMBL364421 | 0.80 | PROKR1 (0.38) | TLR9TLR7TLR8HTR2CPROKR1 | |
| SCHEMBL364583 | 0.78 | TLR9 (0.38) | TLR9TLR7TLR8HTR2CHTR1A | |
| SCHEMBL364904 | 0.77 | TLR8 (0.38) | TLR7TLR8PROKR1 | |
| SCHEMBL363321 | 0.77 | TLR9 (0.36) | TLR9TLR7TLR8HTR2CHTR6 | |
| SCHEMBL364546 | 0.73 | MEN1 (0.31) | PROKR1 | |
| SCHEMBL363467 | 0.73 | MEN1 (0.31) | PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |