Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylbutazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.82 |
| ▸ | RAB9A | P51151 | 3/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylbutazone SCHEMBL8005041 | 1.00 | RAB9A (0.82) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL2122724 | 0.98 | RAB9A (0.80) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL21694456 | 0.98 | RAB9A (0.80) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL2874252 | 0.98 | RAB9A (0.80) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL7715162 | 0.98 | RAB9A (0.80) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL10913190 | 0.98 | RAB9A (0.80) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| SCHEMBL29489697 | 0.93 | ALDH1A1 (0.73) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Phenylbutazone SCHEMBL11269971 | 0.92 | ALDH1A1 (0.72) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25857 | 0.91 | LMNA (1.00) | RAB9AALDH1A1CYP3A4LMNAPTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25856 | 0.91 | LMNA (1.00) | RAB9AALDH1A1CYP3A4LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 62836 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| CN-121856715-B | Method for judging ground fault of power distribution network and centralized protection measurement and control device | 珠海菲森电力科技有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4744679-A1 | USE OF POLYLACTIC ACID AND COPOLYMER THEREOF IN PREPARATION OF DRUGS FOR PROMOTING TENDON/LIGAMENT GROWTH | Changchun Sinobiomaterials Co., Ltd. (CN) | 2026-05-20 | — | — | EP | claimed |
| CN-121580084-B | Concrete pouring process monitoring method and system based on multi-source data | 中国建筑第八工程局有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-116449143-B | Relay protection device action time evaluation method and system based on machine learning algorithm | 中国电力科学研究院有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119864772-B | Single-phase earth fault control method and system | 国网浙江省电力有限公司瑞安市供电公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260132404-A1 | MODIFIED OLIGONUCLEOTIDES AND DOUBLE-STRANDED RNAS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130928-A1 | COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN | ASCENTAWITS PHARMACEUTICALS LTD (CN) | 2026-05-14 | — | — | US | claimed |
| CN-122026283-A | Longitudinal impedance differential protection method | 华中科技大学 | 2026-05-12 | — | — | CN | claimed |
| WO-1980000661-A1 | PHARMACEUTICAL PREPARATIONS | CROFT J (NZ) | 1980-04-17 | — | — | WO | claimed |
| EP-0010061-A1 | Pharmaceutical preparations containing a mollusc extract | Mc Farlane, Stuart John (NZ) | 1980-04-16 | — | — | EP | claimed |
| US-4198402-A | TO REDUCE ULCER-LESION FORMATION | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1980-04-15 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4169147-A | Novel transient pro-drug forms of phenylbutazone and oxyphenbutazone in compositions and methods of use | INTERX RESEARCH CORPORATION (US) | 1979-09-25 | — | — | US | claimed |
| US-4168308-A | Composition for enhancing the administration of pharmacologically active agents | APOTEKSVARUCENTRALEN VITRUM AB (SE) | 1979-09-18 | — | — | US | claimed |
| US-4151292-A | ANTIINFLAMMATORY SIDE EFFECT INHIBITION USING CHROMENE DERIVATIVES, GASTROINTESTINAL DISORDERS | FISONS LIMITED (GB) | 1979-04-24 | — | — | US | claimed |
| US-4016268-A | CO-ADMINISTERING A BISMUTH SUBSALICYLATE AND AN ANTIINFLAMMATORY AGENT | MORTON-NORWICH PRODUCTS, INC. (US) | 1977-04-05 | — | — | US | claimed |
| US-4004002-A | PREVENT GASTRIC IRRITATION | A. H. ROBINS COMPANY, INCORPORATED (US) | 1977-01-18 | — | — | US | claimed |
| US-3993767-A | ANTIINFLAMMATORY AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-11-23 | — | — | US | claimed |