Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL187681 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL2548589 | 0.95 | TSHR (0.82) | — | |
| Maleic Acid SCHEMBL10873082 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL2548587 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL6875 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL2046433 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL3998225 | 0.95 | — | — | |
| Maleic Acid SCHEMBL20487516 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL615 | 0.95 | — | — | |
| Maleic Acid SCHEMBL2046430 | 0.95 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446458-B1 | ADHESIVES FOR BONDING PEROXIDE-CURED ELASTOMERS | LORD CORP (US) | 2006-07-19 | — | — | EP | claimed |
| EP-1446458-A2 | ADHESIVES FOR BONDING PEROXIDE-CURED ELASTOMERS | Lord Corporation (US) | 2004-08-18 | — | — | EP | claimed |
| WO-2004016677-A1 | PHENOLIC ADHESIVES FOR BONDING PEROXIDE-CURED ELASTOMERS | LORD CORPORATION (US) | 2004-02-26 | — | — | WO | claimed |
| US-20040033374-A1 | Phenolic adhesives for bonding peroxide-cured elastomers | LORD CORPORATION | 2004-02-19 | — | — | US | claimed |
| WO-2003044115-A2 | ADHESIVES FOR BONDING PEROXIDE-CURED ELASTOMERS | LORD CORPORATION (US) | 2003-05-30 | — | — | WO | claimed |
| US-6512039-B1 | A peroxide-cured elastomer adhesive composition, said composition absent a reactive nitroso group containing compound and consisting essentially of a diluent, a film former, a polymaleimide compound, a precipitated silica, and | LORD CORPORATION | 2003-01-28 | — | — | US | claimed |
| EP-1244739-A1 | SMOKE AND FIRE RETARDANT PLENUM COMPOSITIONS | Georgia Gulf Corporation (US) | 2002-10-02 | — | — | EP | claimed |
| US-6268422-B1 | POLYVINYL ALCOHOL STABILIZED BUTADIENE POLYMER LATEX FORMED BY EMULSION POLYMERIZATION AND METHYLENE DONORS | LORD CORPORATION | 2001-07-31 | — | — | US | claimed |
| WO-2001036530-A1 | SMOKE AND FIRE RETARDANT PLENUM COMPOSITIONS | GEORGIA GULF CORPORATION (US) | 2001-05-25 | — | — | WO | claimed |
| WO-1999060055-A1 | METHOD FOR REDUCING EXTRACTABLE HEAVY METALS (LEAD) FROM HALOGENATED POLYMER COMPOSITIONS | HAMMOND GROUP, INC. (US) | 1999-11-25 | — | — | WO | claimed |
| EP-0728149-A1 | AQUEOUS ADHESIVE FOR BONDING ELASTOMERS | LORD CORPORATION (US) | 1996-08-28 | — | — | EP | claimed |
| WO-1995013304-A1 | AQUEOUS ADHESIVE FOR BONDING ELASTOMERS | LORD CORPORATION (US) | 1995-05-18 | — | — | WO | claimed |
| US-5367010-A | Mixtures with phenolic resins and aromatic nitroso compounds | LORD CORPORATION (US) | 1994-11-22 | — | — | US | claimed |
| US-5236981-A | STABILIZED HALOGENATED POLYMER COMPOSITIONS CONTAINING A LEAD OR ORGANOTIN COMPOUND | RHONE-POULENC CHIMIE (FR) | 1993-08-17 | — | — | US | claimed |
| WO-1992020526-A1 | LASER MARKING OF FLUOROPOLYMERS | RAYCHEM LIMITED (GB) | 1992-11-26 | — | — | WO | claimed |
| EP-0144126-A1 | Semi-conductive heating cable | EATON CORPORATION (US) | 1985-06-12 | — | — | EP | claimed |
| US-4520260-A | DIELECTRIC JACKET IS RADIATION CROSSLINKED PRODUCT OF ELASTOMER, POLYOLEFIN AND HEAT STABILIZER | EATON CORPORATION (US) | 1985-05-28 | — | — | US | claimed |
| US-4401783-A | BLEND OF POLYOLEFIN AND VULCANIZED OLEFIN COPOLYMER | EATON CORPORATION (US) | 1983-08-30 | — | — | US | claimed |
| US-4293663-A | SHAPING, CURING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1981-10-06 | — | — | US | claimed |
| US-4119587-A | Adhesive compositions comprising (a) halogenated polyolefin (b) aromatic nitroso compound and (c) lead salts | LORD CORPORATION (US) | 1978-10-10 | — | — | US | claimed |