Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362281 | 0.94 | GPBAR1 (0.48) | GPBAR1BCL2L1BADBRD4EPHX2 | |
| SCHEMBL364353 | 0.92 | GPBAR1 (0.47) | GPBAR1BCL2L1BADBRD4EPHX2 | |
| SCHEMBL363178 | 0.89 | GPBAR1 (0.51) | GPBAR1BRD4RXRAGRM1MEN1 | |
| SCHEMBL363976 | 0.89 | GPBAR1 (0.41) | GPBAR1BRD4EPHX2MEN1KMT2A | |
| SCHEMBL362457 | 0.88 | GPBAR1 (0.48) | GPBAR1BRD4RXRAMAPK1MAP2K4 | |
| SCHEMBL364601 | 0.88 | GPBAR1 (0.66) | GPBAR1BRD4RXRAGRIK1GRIK2 | |
| SCHEMBL362545 | 0.88 | GPBAR1 (0.66) | GPBAR1BRD4RXRAGRIK1GRIK2 | |
| SCHEMBL363349 | 0.88 | GPBAR1 (0.66) | GPBAR1BRD4RXRAGRIK1GRIK2 | |
| SCHEMBL364467 | 0.88 | GPBAR1 (0.39) | GPBAR1EPHX2MEN1CYP1A2KMT2A | |
| SCHEMBL363176 | 0.88 | GPBAR1 (0.39) | GPBAR1EPHX2MEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |