Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GART | P22102 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.33 |
| ▸ | GCG | P01275 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363619 | 0.93 | GPBAR1 (0.39) | GPBAR1EPHX2SLC6A9BRD4ALDH1A1 | |
| SCHEMBL363289 | 0.90 | GPBAR1 (0.41) | GPBAR1EPHX2SLC6A9BRD4EGLN1 | |
| SCHEMBL363235 | 0.89 | GPBAR1 (0.51) | GPBAR1EPHX2BRD4MEN1MAPK1 | |
| SCHEMBL362350 | 0.86 | GPBAR1 (0.48) | GPBAR1EPHX2SLC6A9BRD4MAPT | |
| SCHEMBL363293 | 0.85 | GPBAR1 (0.39) | GPBAR1BRD4ALDH1A1MEN1LMNA | |
| SCHEMBL362551 | 0.85 | GPBAR1 (0.38) | GPBAR1ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL1390253 | 0.84 | GPBAR1 (0.41) | GPBAR1SLC6A9BRD4EGLN1KMT2A | |
| SCHEMBL1390250 | 0.84 | GPBAR1 (0.41) | GPBAR1SLC6A9BRD4EGLN1KMT2A | |
| SCHEMBL362887 | 0.83 | GPBAR1 (0.39) | GPBAR1BRD4EGLN1ALDH1A1MEN1 | |
| SCHEMBL362281 | 0.83 | GPBAR1 (0.48) | GPBAR1EPHX2BRD4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |