Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630740 | 0.88 | ALDH1A1 (0.53) | ALDH1A1ATMPTGS2NR4A2MAPT | |
| SCHEMBL2920694 | 0.88 | LMNA (0.53) | ALDH1A1PTGS2TDO2NR4A2PTGS1 | |
| SCHEMBL1558375 | 0.84 | TDO2 (0.44) | PTGS2TDO2NR4A2PTGS1MAPT | |
| SCHEMBL2079006 | 0.80 | CNR1 (0.47) | PTGS2TDO2NR4A2PTGS1F2 | |
| SCHEMBL6598809 | 0.78 | TDO2 (0.49) | PTGS2TDO2PTGS1SPR | |
| SCHEMBL16205922 | 0.78 | NR4A2 (0.67) | ALDH1A1ATMNR4A2PIM1PIM3 | |
| SCHEMBL15652258 | 0.76 | ALDH1A1 (0.61) | ALDH1A1ATMNR4A2PIM1PIM3 | |
| SCHEMBL214780 | 0.76 | ALDH1A1 (0.61) | ALDH1A1ATMNR4A2PIM1PIM3 | |
| SCHEMBL23612225 | 0.75 | GAA (0.58) | NR4A2MAPTLMNASPR | |
| SCHEMBL26204498 | 0.74 | NR4A2 (0.65) | ALDH1A1ATMNR4A2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | claimed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |