Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 6/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chromone SCHEMBL3710911 | 0.92 | MAOA (0.58) | MAOAMAOBFTOCLK1DYRK1A | |
| Chromone SCHEMBL27499544 | 0.85 | MAOA (0.36) | MAOAMAOBFTO | |
| Piperidine SCHEMBL5332373 | 0.81 | OXTR (0.43) | HTR2AHTR2CGHSRCLK1DYRK1A | |
| Chromone SCHEMBL4013021 | 0.79 | MAOA (0.30) | MAOAMAOBFTO | |
| Aziridine SCHEMBL31305856 | 0.76 | OXTR (0.47) | MAOBHTR2AHTR2CGHSRCLK1 | |
| Chromone SCHEMBL28193584 | 0.76 | MAOA (0.66) | MAOAMAOBFTODYRK1AACHE | |
| Coumarin SCHEMBL3632884 | 0.75 | CA12 (0.48) | GHSRCLK1DYRK1ADYRK1BACHE | |
| Piperidine SCHEMBL11599158 | 0.73 | OXTR (0.44) | MAOBHTR2AHTR2C | |
| Chromone SCHEMBL28327088 | 0.71 | MAOA (0.95) | MAOAMAOBFTODYRK1AACHE | |
| Chromone SCHEMBL27978219 | 0.71 | MAOA (0.95) | MAOAMAOBFTODYRK1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141994-A1 | MULTI-RING COMPOUNDS AND USES THEREOF | Avalon Pharmaceuticals (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008133975-A1 | MULTI-RING COMPOUNDS AND USES THEREOF | AVALON PHARMACEUTICALS (US) | 2008-11-06 | — | — | WO | disclosed |