Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956393 | 0.86 | SMN1; SMN2 (0.55) | L3MBTL1POLBCYP2D6CYP2C9MEN1 | |
| SCHEMBL29896794 | 0.86 | SMN1; SMN2 (0.55) | L3MBTL1POLBCYP2D6CYP2C9MEN1 | |
| SCHEMBL4553814 | 0.82 | L3MBTL1 (0.48) | L3MBTL1POLBCYP2D6CYP2C9MEN1 | |
| SCHEMBL14567692 | 0.80 | POLB (0.46) | L3MBTL1POLBCYP2D6CYP2C9HSD17B3 | |
| SCHEMBL21459349 | 0.76 | ALDH1A1 (0.50) | L3MBTL1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31303303 | 0.76 | ALDH1A1 (0.50) | L3MBTL1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12043660 | 0.76 | SMN1; SMN2 (0.53) | L3MBTL1POLBCYP2D6CYP2C9MEN1 | |
| SCHEMBL1102396 | 0.75 | L3MBTL1 (0.49) | L3MBTL1CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL17174249 | 0.75 | OPRM1 (0.48) | POLBOPRM1OPRK1OPRL1NOTUM | |
| SCHEMBL1536266 | 0.74 | CHRM2 (0.37) | CYP2D6CYP2C9MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119677737-A | Heteroaryl compounds for the treatment of pain | 沃泰克斯药物股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-119546580-A | Heteroaryl compounds for the treatment of pain | 沃泰克斯药物股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-112689633-B | For inhibiting Nav1.8 Pyridinecarboxamide Compounds | 利伯研究所公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-114945566-B | Substituted tetrahydrofurans as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118852478-A | Sulfated glycosaminoglycan biomaterials as proteoglycan mimics | 格莱克罗吉克斯公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-115697352-B | Sulfated glycosaminoglycan biomaterials as proteoglycan mimics | 格莱克罗吉克斯公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-117940166-A | SOS1 inhibitors and RAS inhibitors for the treatment of pain | 塞文莱斯治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-112689629-B | For inhibiting Nav1.8 Pyridazine Compounds | 利伯研究所公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-110612285-B | Amide derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2023-04-04 | — | — | CN | disclosed |
| EP-2155727-A1 | N-[6-AMINO-5-(PHENYL)PYRAZIN-2-YL]-ISOXAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NAV1.8 CHANNEL MODULATORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008135830-A1 | N- [6-AMINO-S- (PHENYL) PYRAZIN-2-YL] -ISOXAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NAV1.8 CHANNEL MODULATORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |