Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.66 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.49 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5008149 | 1.00 | HSP90AB1 (0.66) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8122858 | 0.97 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3633461 | 0.97 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8122674 | 0.88 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3632103 | 0.88 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3630352 | 0.88 | HSP90AB1 (0.79) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| Hydrochloric Acid SCHEMBL5009934 | 0.88 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8141540 | 0.88 | HSP90AB1 (0.79) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| Hydrochloric Acid SCHEMBL3630521 | 0.88 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3632189 | 0.87 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146967-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | Serenex, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008130879-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | SERENEX, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080269193-A1 | Tetrahydroindole and Tetrahydroindazole Derivatives | SERENEX, INC. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269193-A1 | Tetrahydroindole and Tetrahydroindazole Derivatives | HSF1, HSP90AB1, TPH1 | HSP90AB1 2/4885HSP90AA1 4/4885HSP90B1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.