Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12985542 | 0.90 | MAPK8 (0.48) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3634925 | 0.87 | MAPK8 (0.49) | MAPK8MAPK9MAPK10ALDH1A1HSD17B10 | |
| SCHEMBL3634689 | 0.86 | MAPK8 (0.42) | MAPK8MAPK9MAPK10ALDH1A1MEN1 | |
| SCHEMBL3638919 | 0.86 | MAPK8 (0.43) | MAPK8MAPK9MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL3631272 | 0.86 | MAPK8 (0.44) | MAPK8MAPK9MAPK10ALDH1A1KDM4E | |
| SCHEMBL3635595 | 0.83 | MAPK8 (0.40) | MAPK8MAPK9ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3637497 | 0.83 | MAPK8 (0.41) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL3945638 | 0.82 | MAPK8 (0.39) | MAPK8MAPK9MAPK10ALDH1A1MEN1 | |
| SCHEMBL3940003 | 0.82 | MAPK8 (0.52) | MAPK8MAPK9MAPK10MAPT | |
| SCHEMBL3636491 | 0.81 | TP53 (0.40) | MAPK8MAPK9ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |