Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637497 | 0.89 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MCL1ALDH1A1 | |
| SCHEMBL3634925 | 0.88 | MAPK8 (0.49) | MAPK8MAPK9MAPK10MCL1ALDH1A1 | |
| SCHEMBL12985542 | 0.88 | MAPK8 (0.48) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3633153 | 0.86 | MAPK8 (0.41) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL3634381 | 0.85 | MAPK8 (0.53) | MAPK8MAPK9MAPK10SMN1; SMN2MEN1 | |
| SCHEMBL3634689 | 0.84 | MAPK8 (0.42) | MAPK8MAPK9MAPK10ALDH1A1MEN1 | |
| SCHEMBL3631272 | 0.83 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MCL1KDM4E | |
| SCHEMBL3945638 | 0.83 | MAPK8 (0.39) | MAPK8MAPK9MAPK10ALDH1A1MEN1 | |
| SCHEMBL3635595 | 0.81 | MAPK8 (0.40) | MAPK8MAPK9KDM4EALDH1A1CYP2C9 | |
| SCHEMBL3940003 | 0.80 | MAPK8 (0.52) | MAPK8MAPK9MAPK10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |