Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634689 | 0.89 | MAPK8 (0.42) | MAPK8MAPK9MEN1LMNAKMT2A | |
| SCHEMBL3631272 | 0.88 | MAPK8 (0.44) | MAPK8MAPK9MEN1LMNAKMT2A | |
| SCHEMBL12985542 | 0.85 | MAPK8 (0.48) | MAPK8MAPK9 | |
| SCHEMBL3634925 | 0.84 | MAPK8 (0.49) | MAPK8MAPK9ALDH1A1USP2TSHR | |
| SCHEMBL3940003 | 0.84 | MAPK8 (0.52) | MAPK8MAPK9MAPTRAB9ALMNA | |
| SCHEMBL3945638 | 0.84 | MAPK8 (0.39) | MAPK8MAPK9MEN1KMT2AALDH1A1 | |
| SCHEMBL3636491 | 0.84 | TP53 (0.40) | MAPK8MAPK9MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3634026 | 0.83 | MAPK8 (0.44) | MAPK8MAPK9MEN1KMT2A | |
| SCHEMBL3633153 | 0.83 | MAPK8 (0.41) | MAPK8MAPK9MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3637957 | 0.83 | MAPK8 (0.45) | MAPK8MAPK9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |