Sugi Predict

Sugi Predict / Compounds / SCHEMBL363341

SCHEMBL363341

SCHEMBL363341

COc1c(C)cc(Br)cc1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.45
▸ PKM P14618 1/20 0.45
▸ CA2 P00918 1/20 0.42
▸ CA4 P22748 1/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ ACHE P22303 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.39
▸ NQO2 P16083 1/20 0.38
▸ MAPT P10636 4/20 0.37
▸ HTT P42858 2/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ ALOX15 P16050 1/20 0.36
▸ ALOX12 P18054 1/20 0.36
▸ TUBB4A P04350 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28586799 0.97 KDM4E (0.44) KDM4EPKMCA2CA4HSD17B10
SCHEMBL4735982 0.97 KDM4E (0.44) KDM4EPKMCA2CA4HSD17B10
SCHEMBL11216824 0.87 HSD17B10 (0.52) KDM4EPKMCA2CA4HSD17B10
SCHEMBL11933625 0.85 ACHE (0.50) KDM4EPKMCA2CA4ACHE
SCHEMBL14394921 0.85 KDM4E (0.41) KDM4EPKMCA2CA4HSD17B10
SCHEMBL16904136 0.84 TDP1 (0.48) KDM4EPKMHSD17B10ALDH1A1MAPT
SCHEMBL931631 0.84 POLB (0.44) KDM4EPKMCA2CA4HSD17B10
SCHEMBL30017049 0.84 KDM4E (0.43) KDM4EPKMCA2CA4HSD17B10
SCHEMBL930657 0.84 KDM4E (0.40) KDM4EPKMCA2CA4HSD17B10
SCHEMBL19607300 0.84 KDM4E (0.43) KDM4EPKMCA2CA4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114853795-A Arylboron compound of conjugated olefin and preparation method and application thereof 南京工业大学 2022-08-05 — — CN claimed
CN-109232936-B Anion exchange membrane for all-vanadium redox flow battery and preparation method thereof 福州大学 2020-11-03 — — CN claimed
US-20160254449-A1 HOLE TRANSPORT MATERIAL MERCK PATENT GMBH (DE) 2016-09-01 — — US claimed
EP-3052470-A1 HOLE TRANSPORT MATERIAL Merck Patent GmbH (DE) 2016-08-10 — — EP claimed
WO-2015049031-A1 HOLE TRANSPORT MATERIAL MERCK PATENT GMBH (DE) 2015-04-09 — — WO claimed
US-20250289821-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2025-09-18 — — US disclosed
US-12410212-B2 Cyclic compound having selective KRAS inhibitory effect on HRAS and NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-09-09 — — US disclosed
EP-3852748-B1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF LILLY CO ELI (US) 2025-09-03 — — EP disclosed
EP-4603105-A1 PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-08-20 — — EP disclosed
EP-4596543-A2 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF Organovo, Inc. (US) 2025-08-06 — — EP disclosed
EP-4592308-A1 CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-07-30 — — EP disclosed
US-20250230193-A1 CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS CHUGAI PHARMACEUTICAL CO LTD (JP) 2025-07-17 — — US disclosed
EP-0300772-A1 Catalyst for polymerization of conjugated diene and process for producing conjugated diene polymer JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1989-01-25 — — EP disclosed
US-4792570-A 3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents SYNTEX (U.S.A.) INC. (US) 1988-12-20 — — US disclosed
EP-0293078-A1 Pharmaceutically active amines THE UPJOHN COMPANY (US) 1988-11-30 — — EP disclosed
WO-1988008424-A1 PHARMACEUTICALLY ACTIVE AMINES THE UPJOHN COMPANY (US) 1988-11-03 — — WO disclosed
EP-0157652-A1 2-, 3- And 4-biphenyloxyaminoalkanes and related compounds, their preparation and uses, and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1985-10-09 — — EP disclosed
US-4391995-A 4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture HOECHST AKTIENGESELLSCHAFT (DE) 1983-07-05 — — US disclosed
US-4301295-A ANTILIPEMIC AND ANTICHOLESTEROL AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1981-11-17 — — US disclosed
US-4238626-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1980-12-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12410212-B2 Cyclic compound having selective KRAS inhibitory effect on HRAS and NRAS KRAS, HRAS, NRAS KDM4E 3251/4885PKM 4448/4885CA2 2914/4885
US-20250289821-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF NR1H4, NR1H2, NR1H3 KDM4E 4790/4885PKM 3273/4885CA2 4235/4885
US-20160254449-A1 HOLE TRANSPORT MATERIAL SUN2, SLC6A19, SLCO2A1 KDM4E 2048/4885PKM 1942/4885CA2 4480/4885
US-20250230193-A1 CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS KRAS, HRAS, NRAS KDM4E 3251/4885PKM 4448/4885CA2 2914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.