Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644965 | 0.91 | MAPK1 (0.59) | ALDH1A1MAPTGAAMAPK1HDAC3 | |
| SCHEMBL29904721 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL463597 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL8631475 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTGAAMAPK1HDAC3 | |
| SCHEMBL29154642 | 0.80 | KDM4E (0.60) | ALDH1A1MAPTGAAHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL11503558 | 0.80 | HDAC1 (0.59) | ALDH1A1MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL1953684 | 0.80 | MAPT (0.62) | ALDH1A1MAPTGAAHDAC3HDAC1 | |
| SCHEMBL29581227 | 0.80 | MAPT (0.62) | ALDH1A1MAPTGAAHDAC3HDAC1 | |
| SCHEMBL9214730 | 0.79 | MAPK1 (0.47) | ALDH1A1GAAMAPK1HDAC3HDAC1 | |
| SCHEMBL28244511 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTGAAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155674-A1 | AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008136017-A1 | AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-11-13 | — | — | WO | disclosed |