Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28714249 | 0.98 | GABRA1 (0.41) | GABRA1GABRB2MAPTKMT2AHPGD | |
| SCHEMBL20249854 | 0.85 | GABRA1 (0.41) | GABRA1GABRB2MAPTKMT2AHPGD | |
| SCHEMBL6964241 | 0.83 | GABRA1 (0.42) | GABRA1GABRB2MAPTKMT2AHPGD | |
| SCHEMBL18754039 | 0.83 | GABRA1 (0.42) | GABRA1GABRB2MAPTKMT2AHPGD | |
| Ammonia Solution, Strong SCHEMBL28842318 | 0.82 | TRPA1 (0.43) | GABRA1GABRB2MAPTKMT2AHPGD | |
| Phosphine SCHEMBL29240846 | 0.82 | TRPA1 (0.43) | GABRA1GABRB2MAPTKMT2AHPGD | |
| SCHEMBL1826833 | 0.81 | GABRA1 (0.41) | GABRA1GABRB2MAPTKMT2AHPGD | |
| SCHEMBL25845119 | 0.80 | GABRA1 (0.41) | GABRA1GABRB2KMT2AHPGDMYC | |
| SCHEMBL31503044 | 0.80 | TSHR (0.39) | GABRA1GABRB2HPGDTSHRACHE | |
| SCHEMBL20563882 | 0.80 | MYC (0.42) | GABRA1GABRB2HPGDTSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103439-B | 2,7- diaza spiro [3.5] nonane compound | 瑞敏德股份有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-109219602-A | Modulators of cystic fibrosis transmembrane conductance regulator proteins | 艾伯维公司 | 2019-01-15 | — | — | CN | disclosed |
| US-10118916-B2 | Modulators of cystic fibrosis transmembrane conductance regulator protein | ABBVIE S.Á.R.L. (LU) | 2018-11-06 | — | — | US | disclosed |
| EP-3119782-B1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | REMYND NV (BE) | 2018-01-31 | — | — | EP | disclosed |
| WO-2017187321-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN | AbbVie S.à.r.l. (LU) | 2017-11-02 | — | — | WO | disclosed |
| US-20170305891-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN | ABBVIE S.Á.R.L. (LU) | 2017-10-26 | — | — | US | disclosed |
| US-9750745-B2 | 2,7-diazaspiro[3.5]nonane compounds | REMYND NV (BE) | 2017-09-05 | — | — | US | disclosed |
| US-20170157137-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | REMYND NV (BE) | 2017-06-08 | — | — | US | disclosed |
| EP-1368295-B1 | PROCESS FOR THE MANUFACTURE OF PHENYLACETIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-9617264-B2 | 2,7-diazaspiro[3.5]nonane compounds | REMYND NV (BE) | 2017-04-11 | — | — | US | disclosed |
| EP-3119782-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | reMynd NV (BE) | 2017-01-25 | — | — | EP | disclosed |
| US-20170015665-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | REMYND NV (BE) | 2017-01-19 | — | — | US | disclosed |
| CN-106103439-A | 2,7 diaza spiros [3.5] nonane compound | 瑞敏德股份有限公司 | 2016-11-09 | — | — | CN | disclosed |
| WO-2015140132-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | REMYND NV (BE) | 2015-09-24 | — | — | WO | disclosed |
| EP-2145042-A1 | TEXTILE SCENTING | Henkel AG & Co. KGaA (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008135306-A1 | TEXTILE SCENTING | HENKEL AG & CO. KGAA (DE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2007007347-A1 | INDUSTRIAL PROCESS OF FEXOFENADINE HYDROCHLORIDE WITH CONTROLLED SIDE PRODUCTS | WOCKHARDT LIMITED (IN) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157137-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | PSEN1, MAPT, PSEN2 | GABRA1 2430/4885GABRB2 2540/4885MAPT 2/4885 |
| US-20170015665-A1 | 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS | PSEN1, MAPT, PSEN2 | GABRA1 2430/4885GABRB2 2540/4885MAPT 2/4885 |
| US-20170305891-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN | CFTR, CHRM2, CHRM1 | GABRA1 2211/4885GABRB2 3073/4885MAPT 4880/4885 |
| US-10118916-B2 | Modulators of cystic fibrosis transmembrane conductance regulator protein | CFTR, CHRM2, CHRM1 | GABRA1 2211/4885GABRB2 3073/4885MAPT 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.