Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12037745 | 0.74 | KDM4E (0.42) | ERN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL28796378 | 0.73 | CYP2A6 (0.37) | HPGDCYP2A6LMNA | |
| SCHEMBL29267034 | 0.73 | IDO1 (0.36) | PIM1HPGDLMNA | |
| SCHEMBL30993119 | 0.70 | CYP2A6 (0.41) | ERN1PIM3PIM1CYP2A6 | |
| SCHEMBL28796435 | 0.70 | ERN1 (0.41) | ERN1ALDH1A1CYP1A2MAPTHTT | |
| SCHEMBL31698302 | 0.69 | NOS1 (0.42) | ERN1ALDH1A1CYP1A2CYP2C19HPGD | |
| SCHEMBL3636860 | 0.69 | CYP19A1 (0.38) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL28356912 | 0.68 | PIM3 (0.41) | ERN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29635192 | 0.66 | NPY5R (0.43) | ALDH1A1PIM1GAAMAPTHTT | |
| SCHEMBL28796377 | 0.66 | NPY5R (0.43) | ALDH1A1PIM1GAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |