Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634689 | 0.90 | MAPK8 (0.42) | MAPK8MEN1KMT2AMAPK9 | |
| SCHEMBL3637957 | 0.90 | MAPK8 (0.45) | MAPK8MAPK9 | |
| SCHEMBL3631272 | 0.88 | MAPK8 (0.44) | MAPK8MEN1KMT2AMAPK9MCL1 | |
| SCHEMBL3636491 | 0.87 | TP53 (0.40) | MAPK8MAPK9POLB | |
| SCHEMBL3940003 | 0.84 | MAPK8 (0.52) | MAPK8MAPK9 | |
| SCHEMBL12985542 | 0.83 | MAPK8 (0.48) | MAPK8MAPK9 | |
| SCHEMBL3635595 | 0.83 | MAPK8 (0.40) | MAPK8MEN1KMT2AMAPK9 | |
| SCHEMBL14604052 | 0.83 | MAP2 (0.40) | MAPK8MEN1KMT2AMAPK9 | |
| SCHEMBL14604161 | 0.83 | MAPK8 (0.39) | MAPK8MEN1KMT2AMAPK9 | |
| SCHEMBL14604008 | 0.83 | MAPK8 (0.48) | MAPK8MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |