Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25245654 | 0.88 | SMN1; SMN2 (0.42) | L3MBTL1SMN1; SMN2ALDH1A1USP2ADORA1 | |
| SCHEMBL3629291 | 0.87 | NR1H2 (0.40) | L3MBTL1SMN1; SMN2ALDH1A1USP2ADORA1 | |
| SCHEMBL26103503 | 0.86 | SMN1; SMN2 (0.42) | L3MBTL1SMN1; SMN2ALDH1A1POLBUSP2 | |
| SCHEMBL3634007 | 0.85 | SMN1; SMN2 (0.37) | L3MBTL1SMN1; SMN2ALDH1A1USP2ADORA1 | |
| SCHEMBL22233140 | 0.85 | ADORA1 (0.39) | L3MBTL1SMN1; SMN2ALDH1A1USP2ADORA1 | |
| SCHEMBL426525 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1POLBUSP2HTT | |
| SCHEMBL22233978 | 0.81 | ALDH1A1 (0.34) | L3MBTL1SMN1; SMN2ALDH1A1POLBUSP2 | |
| SCHEMBL13118618 | 0.80 | CYP4F2 (0.44) | L3MBTL1SMN1; SMN2ALDH1A1USP2ADORA1 | |
| SCHEMBL23390475 | 0.80 | SMN1; SMN2 (0.36) | L3MBTL1SMN1; SMN2ALDH1A1POLBUSP2 | |
| SCHEMBL550869 | 0.79 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155666-A1 | AZETIDINE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | Pfizer Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008139287-A1 | AZETIDINE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | PFIZER LIMITED (GB) | 2008-11-20 | — | — | WO | disclosed |
| US-20080280877-A1 | Azetidines | PFIZER INC | 2008-11-13 | — | — | US | disclosed |
| US-20080280877-A1 | Azetidines | PFIZER INC | 2008-11-13 | — | — | US | disclosed |
| US-20080280877-A1 | Azetidines | PFIZER INC | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280877-A1 | Azetidines | PTGER2, PTGER1, PTGDR2 | L3MBTL1 4870/4885SMN1; SMN2 3965/4885ALDH1A1 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.