Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560511 | 0.88 | SRD5A2 (0.40) | SRD5A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3634756 | 0.85 | MAOA (0.45) | SRD5A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3027681 | 0.83 | NR1H2 (0.42) | SRD5A2KDM4EHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL13560478 | 0.83 | SRD5A2 (0.40) | SRD5A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3639124 | 0.81 | SRD5A2 (0.69) | SRD5A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13560509 | 0.80 | MAOA (0.35) | SRD5A2KDM4EMAOAKMT2AMEN1 | |
| SCHEMBL3023791 | 0.78 | MAOA (0.43) | HPGDMAOAKMT2AMEN1TDP1 | |
| SCHEMBL3637426 | 0.76 | ABCB11 (0.45) | SRD5A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3675353 | 0.76 | KDM4E (0.42) | SRD5A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13560475 | 0.75 | MAOA (0.37) | SRD5A2MAOAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |