Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485306 | 0.83 | LMNA (0.81) | LMNAMAPK1RAB9AHRH3MEN1 | |
| SCHEMBL28393218 | 0.83 | LMNA (0.58) | LMNAHRH3SMN1; SMN2KMT2A | |
| SCHEMBL996088 | 0.83 | LMNA (0.53) | LMNAMAPK1RAB9AHRH3 | |
| SCHEMBL24474658 | 0.83 | LMNA (0.58) | LMNARAB9APOLBHRH3SMN1; SMN2 | |
| SCHEMBL24474667 | 0.83 | LMNA (0.58) | LMNAMAPK1RAB9AHRH3GRIN1 | |
| SCHEMBL5730065 | 0.81 | LMNA (0.78) | LMNAMAPK1RAB9AGRM5HRH3 | |
| SCHEMBL6158667 | 0.81 | LMNA (0.44) | LMNAMAPK1RAB9AHRH3SMN1; SMN2 | |
| SCHEMBL31673107 | 0.81 | CYP2A6 (0.51) | LMNAGRM5 | |
| SCHEMBL25747232 | 0.80 | LMNA (0.64) | LMNAGRM5HRH3 | |
| SCHEMBL25376554 | 0.79 | FFAR1 (0.50) | LMNAMAPK1RAB9AHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875552-B | Amino-substituted 1,2, 3-triazole compound and synthesis method and application thereof | 海南师范大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-110590627-B | Synthesis method of 3-aryl thiopropionamide derivative | 温州大学 | 2022-01-14 | — | — | CN | disclosed |
| CN-111875552-A | Amino-substituted 1,2, 3-triazole compound and synthesis method and application thereof | 海南师范大学 | 2020-11-03 | — | — | CN | disclosed |
| CN-110590627-A | Synthesis method of 3-aryl thiopropionamide derivative | 温州大学 | 2019-12-20 | — | — | CN | disclosed |
| CN-103408433-A | Method for synthesizing propargylamine compounds | UNIV HUNAN | 2013-11-27 | — | — | CN | disclosed |
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |