Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR known ✓ | P14679 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | G6PD | P11413 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IL2 | P60568 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbutin SCHEMBL13313589 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4289558 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL15481351 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL285242 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13956277 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL18175043 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL5438300 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL12998301 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13054606 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL435261 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 36999 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075319-A | Composition, and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075331-A | Arbutin-loaded bletilla striata outer vesicle compound, preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121271827-B | Sucrose phosphorylase mutant and application thereof in synthesis of alpha-arbutin | 山东三元生物科技股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122071680-A | Lacticaseibacillus paracasei strain and separation method and application thereof | 青海瑞湖生物资源开发有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260137715-A1 | AQUEOUS FORMULATION INCLUDING DISSOLVED HYDROGEN GAS AND MINERALS AND ADDITIVES | BEST PLANET SCIENCE LLC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137644-A1 | COMPOSITIONS INCLUDING CAFFEIC ACID PHENETHYL ESTER | XMK THERAPEUTICS INC. (CA) | 2026-05-21 | — | — | US | claimed |
| CN-122031581-A | Composition for preventing, treating and/or relieving hyperuricemia and application thereof | 广西医科大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031290-A | Percutaneous permeation promoting system and preparation method and application thereof | 北京工商大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122005344-A | High-solubility and high-stability glabridin whitening oil and preparation method thereof | 广东梵蜜琳生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122024870-A | Quantum chemical screening method for extracting arbutin | 苏州科技大学 | 2026-05-12 | — | — | CN | claimed |
| US-4624919-A | Enzymatic production of phospholipid-saccharide derivatives | MEITO SANGYO KABUSHIKI KAISHA (JP) | 1986-11-25 | — | — | US | claimed |
| US-4620850-A | HYDROXYBENZOLFURANONE | WELLA AKTIENGESELLSCHAFT (DE) | 1986-11-04 | — | — | US | claimed |
| EP-0152852-A2 | Antimicrobial agent for treating buildings, building materials, textiles, leather, agricultural products and foodstuffs | PÜHRINGER, Josef, Dr. (SE) | 1985-08-28 | — | — | EP | claimed |
| EP-0125039-A2 | Enzymatic production of phospholipid-saccharide derivatives | MEITO SANGYO KABUSHIKI KAISHA (JP) | 1984-11-14 | — | — | EP | claimed |
| EP-0026474-B1 | COMPOSITION AND PROCESS FOR OXIDATIVE DYEING OF HAIR | Wella Aktiengesellschaft (DE) | 1983-06-08 | — | — | EP | claimed |
| EP-0026473-B1 | OXIDATIVE HAIR-DYEING COMPOSITION | Wella Aktiengesellschaft (DE) | 1983-05-25 | — | — | EP | claimed |
| EP-0026473-A1 | Oxidative hair-dyeing composition | Wella Aktiengesellschaft (DE) | 1981-04-08 | — | — | EP | claimed |
| EP-0026474-A1 | Composition and process for oxidative dyeing of hair | Wella Aktiengesellschaft (DE) | 1981-04-08 | — | — | EP | claimed |
| WO-1981000810-A1 | COMPOSITION ALLOWING THE COLORATION OF HAIR BY OXIDATION | WELLA AG (DE) | 1981-04-02 | — | — | WO | claimed |
| WO-1981000811-A1 | MEANS AND PROCESS ALLOWING HAIR COLORATION BY OXIDATION | WELLA AG (DE) | 1981-04-02 | — | — | WO | claimed |