Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR known ✓ | P14679 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | G6PD | P11413 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IL2 | P60568 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbutin SCHEMBL13313589 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL15481351 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL285242 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13956277 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL18175043 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL36352 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL5438300 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL12998301 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13054606 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL435261 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090263339-A1 | AGENT FOR EXTERNAL APPLICATION TO THE SKIN | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKY (JP) | 2009-10-22 | — | — | US | disclosed |
| EP-1894558-A1 | AGENT FOR EXTERNAL APPLICATION TO THE SKIN | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1054933-B1 | CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES | LUMIGEN INC (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1054933-A4 | CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES | LUMIGEN INC (US) | 2003-07-09 | — | — | EP | disclosed |
| US-6339162-B1 | SOLVOLYSIS OF 4-ACETYLOXYPHENYL-ACETYL-.BETA.-D-GLUCOPYRANOSIDE DERIVATIVE, NEUTRALIZATION WITH ACID, CRYSTALLIZATION OF ARBUTIN OR ITS DERIVATIVE | NISSHIN PHARMA INC. (JP) | 2002-01-15 | — | — | US | disclosed |
| EP-1054933-A1 | CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES | LUMIGEN, INC. (US) | 2000-11-29 | — | — | EP | disclosed |
| EP-1043321-A1 | Process for the preparation of tetrahydropyran derivatives | Nisshin Flour Milling Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999040161-A1 | CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES | LUMIGEN, INC. (US) | 1999-08-12 | — | — | WO | disclosed |
| US-5840963-A | HALOGEN-SUBSTITUTED HYDROQUINONES HAVING ONE HYDROXY GROUP PROTECTED BY PHOSPHATE GROUP | LUMIGEN, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| US-5772926-A | ANALYSIS OF HYDROLYTIC ENZYMES AND ENZYME INHIBITORS; LABELED BINDING PAIRS | LUMIGEN, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| US-5766267-A | USING FIBER REACTIVE DYES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-16 | — | — | US | disclosed |
| EP-0745719-A2 | Use of carbohydrate compounds as auxiliary agents in the dyeing or printing of fibrous materials | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-04 | — | — | EP | disclosed |