Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044650 | 0.84 | MC4R (0.42) | MC4ROPRM1KCNH2GAAOXTR | |
| SCHEMBL3635298 | 0.79 | SLC1A2 (0.42) | SLC1A2 | |
| SCHEMBL3633189 | 0.77 | HTR3E (0.45) | MC4RSLC1A2HTR3EHTR3BHTR3A | |
| SCHEMBL13984355 | 0.75 | MC4R (0.49) | MC4RSLC1A2LMNACHRM2CHRM4 | |
| SCHEMBL3638763 | 0.74 | SLC1A2 (0.46) | MC4RSLC1A2LMNACHRM2CHRM4 | |
| SCHEMBL13044372 | 0.74 | GHSR (0.55) | MC4RLMNACHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL3639303 | 0.74 | MC4R (0.48) | MC4RLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL3730182 | 0.73 | GHSR (0.43) | MC4RLMNAOXTRKDM4EGHSR | |
| SCHEMBL3750634 | 0.73 | GHSR (0.69) | LMNAKDM4EALDH1A1GHSRMEN1 | |
| Hydrochloric Acid SCHEMBL3636742 | 0.72 | GHSR (0.54) | MC4RLMNACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167466-A1 | N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR | Glaxo Group Limited (GB) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008148853-A1 | N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |