Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | NEK4 | P51957 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916278 | 0.85 | POLB (0.70) | POLBMAPTGAACHEK1CHEK2 | |
| SCHEMBL12262808 | 0.84 | POLB (0.68) | POLBMAPTGAAHPGDALDH1A1 | |
| SCHEMBL10131638 | 0.84 | POLB (0.68) | POLBMAPTGAAHPGDALDH1A1 | |
| SCHEMBL10112748 | 0.84 | POLB (0.68) | POLBMAPTGAATP53SMN1; SMN2 | |
| SCHEMBL6646189 | 0.84 | POLB (0.68) | POLBMAPTGAAALDH1A1ADAMTS5 | |
| SCHEMBL6549773 | 0.83 | POLB (0.68) | POLBMAPTGAAADAMTS5MEN1 | |
| SCHEMBL7555227 | 0.82 | POLB (0.62) | POLBMAPTGAAAKT1TP53 | |
| SCHEMBL2772692 | 0.81 | POLB (0.49) | POLBMAPTCHEK1MAP4K4CHEK2 | |
| SCHEMBL24127368 | 0.81 | POLB (0.65) | POLBMAPTGAACHEK1CHEK2 | |
| SCHEMBL31028729 | 0.81 | POLB (0.60) | POLBMAPTGAATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119325464-A | Square amide derivatives as CB1 allosteric modulators | 研究三角协会 | 2025-01-17 | — | — | CN | disclosed |
| US-9926275-B2 | Allosteric modulators of the cannabinoid 1 receptor | NORTHEASTERN UNIVERSITY (US) | 2018-03-27 | — | — | US | disclosed |
| US-9926275-B2 | Allosteric modulators of the cannabinoid 1 receptor | NORTHEASTERN UNIVERSITY (US) | 2018-03-27 | — | — | US | disclosed |
| US-9926275-B2 | Allosteric modulators of the cannabinoid 1 receptor | NORTHEASTERN UNIVERSITY (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160194284-A1 | ALLOSTERIC MODULATORS OF THE CANNABINOID 1 RECEPTOR | NORTHEASTERN UNIVERSITY (US) | 2016-07-07 | — | — | US | disclosed |
| US-20160194284-A1 | ALLOSTERIC MODULATORS OF THE CANNABINOID 1 RECEPTOR | NORTHEASTERN UNIVERSITY (US) | 2016-07-07 | — | — | US | disclosed |
| US-20160194284-A1 | ALLOSTERIC MODULATORS OF THE CANNABINOID 1 RECEPTOR | NORTHEASTERN UNIVERSITY (US) | 2016-07-07 | — | — | US | disclosed |
| WO-2015027160-A2 | ALLOSTERIC MODULATORS OF THE CANNIBINOID 1 RECEPTOR | NORTHEASTERN UNIVERSITY (US) | 2015-02-26 | — | — | WO | disclosed |
| US-8901152-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBVIE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20120277223-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBVIE INC. | 2012-11-01 | — | — | US | disclosed |
| US-8242139-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LABORATORIES (US) | 2012-08-14 | — | — | US | disclosed |
| EP-2452937-A1 | Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme | Abbott Laboratories (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2142521-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080312282-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | US | disclosed |
| WO-2008134693-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |
| EP-1197485-B1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| US-6696469-B2 | FOR TREATMENT OF DISEASES OR PATHOLOGICAL CONDITIONS IN WHICH ENDOTHELIAL DYSFUNCTION IS KNOWN; ATHEROSCLEROSIS, DYSLIPIDAEMIA, DIABETES | LES LABORATOIRES SERVIER (FR) | 2004-02-24 | — | — | US | disclosed |
| US-20020065419-A1 | Cyclobutenedione compounds | LES LABORATOIRES SERVIER (FR) | 2002-05-30 | — | — | US | disclosed |
| EP-1197485-A1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | Les Laboratoires Servier (FR) | 2002-04-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194284-A1 | ALLOSTERIC MODULATORS OF THE CANNABINOID 1 RECEPTOR | CNR1, CNR2, GPR119 | POLB 3492/4885MAPT 3562/4885GAA 3239/4885 |
| US-20080312282-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | DGAT1, DGAT2, LCAT | POLB 2206/4885MAPT 2094/4885GAA 109/4885 |
| US-20120277223-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | DGAT1, DGAT2, LCAT | POLB 2206/4885MAPT 2094/4885GAA 109/4885 |
| US-20020065419-A1 | Cyclobutenedione compounds | NR3C2, NR5A1, CYP11B1 | POLB 630/4885MAPT 3977/4885GAA 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.