Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203701 | 0.91 | SIRT6 (0.61) | SIRT6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3639481 | 0.86 | MAPT (0.43) | SIRT6ALDH1A1LMNAMAPTCHRM2 | |
| SCHEMBL310364 | 0.84 | SIRT6 (0.55) | SIRT6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL25262102 | 0.83 | ALDH1A1 (0.51) | SIRT6ALDH1A1LMNAMAPTCHRM2 | |
| SCHEMBL520097 | 0.82 | MAPT (0.54) | SIRT6ALDH1A1LMNAMAPTCHRM2 | |
| SCHEMBL518300 | 0.81 | ALDH1A1 (0.60) | SIRT6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL518299 | 0.81 | ALDH1A1 (0.60) | SIRT6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL310045 | 0.81 | ALDH1A1 (0.60) | SIRT6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL517794 | 0.80 | ALDH1A1 (0.55) | SIRT6ALDH1A1LMNAMAPTPLK1 | |
| SCHEMBL2062143 | 0.80 | SIRT6 (0.77) | SIRT6ALDH1A1LMNAMAPTPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162454-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150799-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |