Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | PREP | P48147 | 3/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640556 | 0.90 | TMEM97 (0.46) | PARP1TMEM97SIGMAR1PREPFKBP1A | |
| SCHEMBL13567882 | 0.89 | PREP (0.47) | PARP1PREPACE2KLK7NPSR1 | |
| SCHEMBL6610956 | 0.88 | KLK7 (0.50) | PARP1FKBP1AKLK7PRMT5 | |
| SCHEMBL14048084 | 0.84 | ATM (0.44) | — | |
| SCHEMBL8346225 | 0.84 | PRSS1 (0.52) | PARP1TMEM97SIGMAR1FKBP1AKLK7 | |
| SCHEMBL8340452 | 0.84 | PRSS1 (0.52) | PARP1TMEM97SIGMAR1FKBP1AKLK7 | |
| SCHEMBL3354292 | 0.82 | PREP (0.54) | TMEM97SIGMAR1PREPFKBP1AACE2 | |
| SCHEMBL3635836 | 0.81 | HSD17B10 (0.38) | FKBP1A | |
| SCHEMBL9037209 | 0.80 | KLK7 (0.51) | PARP1PREPFKBP1AACE2KLK7 | |
| SCHEMBL30452590 | 0.80 | NPSR1 (0.46) | PREPFKBP1AACE2PRMT5NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155678-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC Neurosciences GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |