Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | GCG | P01275 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364071 | 0.95 | GPBAR1 (0.47) | GPBAR1BRD4EPHX2GCG | |
| SCHEMBL363667 | 0.91 | GPBAR1 (0.42) | GPBAR1BRD4EPHX2SMN1; SMN2 | |
| SCHEMBL364032 | 0.91 | GPBAR1 (0.47) | GPBAR1BRD4EPHX2MAPK1NPC1 | |
| SCHEMBL362350 | 0.90 | GPBAR1 (0.48) | GPBAR1BRD4EPHX2SMN1; SMN2 | |
| SCHEMBL363032 | 0.87 | GPBAR1 (0.45) | GPBAR1BRD4EPHX2 | |
| SCHEMBL363542 | 0.86 | GPBAR1 (0.47) | GPBAR1BRD4EPHX2MAPK1NPC1 | |
| SCHEMBL364239 | 0.86 | GPBAR1 (0.47) | GPBAR1BRD4EPHX2MAPK1NPC1 | |
| SCHEMBL362902 | 0.85 | GPBAR1 (0.45) | GPBAR1BRD4EPHX2MAPK1 | |
| SCHEMBL363678 | 0.85 | GPBAR1 (0.61) | GPBAR1BRD4 | |
| SCHEMBL364242 | 0.83 | GPBAR1 (0.44) | GPBAR1BRD4EPHX2MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |