Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23294460 | 0.86 | DGAT1 (0.37) | DGAT1NPC1TSHRMAPT | |
| SCHEMBL16100174 | 0.84 | DGAT1 (0.38) | DGAT1MAPT | |
| SCHEMBL3028008 | 0.83 | DGAT1 (0.38) | DGAT1PKMKLKB1NPC1GAA | |
| SCHEMBL3028997 | 0.83 | DGAT1 (0.36) | DGAT1PKMKLKB1NPC1GAA | |
| SCHEMBL27284918 | 0.82 | F2RL1 (0.34) | DGAT1PKMKLKB1NPC1GAA | |
| SCHEMBL10117742 | 0.80 | PKM (0.38) | DGAT1PKMKLKB1NPC1GAA | |
| SCHEMBL2122003 | 0.79 | DGAT1 (0.42) | DGAT1BRD4CREBBP | |
| SCHEMBL4799731 | 0.79 | PTGS2 (0.43) | DGAT1PKMNPC1GAATSHR | |
| SCHEMBL12118691 | 0.78 | DGAT1 (0.44) | DGAT1BRD4CREBBP | |
| SCHEMBL13560582 | 0.76 | KLKB1 (0.37) | DGAT1PKMKLKB1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |