Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363780 | 0.84 | PDE10A (0.64) | PDE10A | |
| SCHEMBL362066 | 0.83 | MAPT (0.48) | PDE10AMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL361704 | 0.81 | PDE10A (0.60) | PDE10A | |
| SCHEMBL362739 | 0.76 | PDE10A (0.56) | PDE10A | |
| SCHEMBL363611 | 0.74 | PDE10A (0.62) | PDE10AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL363347 | 0.70 | PDE10A (0.61) | PDE10AALDH1A1TSHR | |
| SCHEMBL369870 | 0.69 | PDE10A (0.64) | PDE10AMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL10099707 | 0.67 | PDE10A (0.58) | PDE10AACP1 | |
| SCHEMBL10099700 | 0.67 | PDE10A (0.58) | PDE10AACP1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL258853 | 0.66 | PDE10A (0.82) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |