Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9762596 | 0.77 | MAPT (0.31) | MAPT | |
| SCHEMBL9526956 | 0.77 | ALDH1A1 (0.32) | MAPTALDH1A1CASP7CASP6HTT | |
| SCHEMBL2453463 | 0.76 | HTT (0.33) | MAPTALDH1A1CASP7CASP6HTT | |
| SCHEMBL2456150 | 0.74 | CCNE2 (0.36) | MAPTHTTCYP1A2CYP2D6CYP2C9 | |
| Ammonia Solution, Strong SCHEMBL28547173 | 0.74 | HTT (0.32) | MAPTHTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14295796 | 0.74 | HTT (0.50) | MAPTALDH1A1CASP7CASP6HTT | |
| SCHEMBL3634566 | 0.74 | DYRK1A (0.31) | MAPTALDH1A1CASP7CASP6CYP1A2 | |
| SCHEMBL29169668 | 0.72 | KDM4E (0.34) | MAPTALDH1A1CASP7CASP6HTT | |
| SCHEMBL28848249 | 0.71 | MAPT (0.33) | MAPTALDH1A1CASP7CASP6HTT | |
| SCHEMBL3632711 | 0.70 | MAPT (0.32) | MAPTHTTGPR35NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155688-B1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | HERAKLES (FR) | 2015-08-05 | — | — | EP | claimed |
| EP-2155688-A2 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | SNPE Matériaux Energétiques (FR) | 2010-02-24 | — | — | EP | claimed |
| US-20090186931-A1 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | ARIANEGROUP SAS (FR) | 2009-07-23 | — | — | US | claimed |
| WO-2008152525-A2 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | SNPE MATERIAUX ENERGETIQUES (FR) | 2008-12-18 | — | — | WO | claimed |
| EP-2155688-B1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | HERAKLES (FR) | 2015-08-05 | — | — | EP | disclosed |
| EP-2155688-B1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | HERAKLES (FR) | 2015-08-05 | — | — | EP | disclosed |
| US-8440839-B2 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | HERAKLES (FR) | 2013-05-14 | — | — | US | disclosed |
| US-8440839-B2 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | HERAKLES (FR) | 2013-05-14 | — | — | US | disclosed |
| US-8440839-B2 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | HERAKLES (FR) | 2013-05-14 | — | — | US | disclosed |
| US-20120323017-A1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM | EURENCO (FR) | 2012-12-20 | — | — | US | disclosed |
| US-20120323017-A1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM | EURENCO (FR) | 2012-12-20 | — | — | US | disclosed |
| US-8273784-B2 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | HERAKLES (FR) | 2012-09-25 | — | — | US | disclosed |
| US-8273784-B2 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | HERAKLES (FR) | 2012-09-25 | — | — | US | disclosed |
| EP-2155688-A2 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | SNPE Matériaux Energétiques (FR) | 2010-02-24 | — | — | EP | disclosed |
| US-20090186931-A1 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | ARIANEGROUP SAS (FR) | 2009-07-23 | — | — | US | disclosed |
| US-20090186931-A1 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | ARIANEGROUP SAS (FR) | 2009-07-23 | — | — | US | disclosed |
| WO-2008152525-A2 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM. | SNPE MATERIAUX ENERGETIQUES (FR) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323017-A1 | DINITROPYRAZOLE DERIVATIVES, THEIR PREPARATION, AND ENERGETIC COMPOSITIONS COMPRISING THEM | NFE2L2, NFE2, RELA | MAPT 3354/4885ALDH1A1 1495/4885CASP7 2839/4885 |
| US-20090186931-A1 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them | NQO2, HRH4, NFE2L2 | MAPT 3611/4885ALDH1A1 2148/4885CASP7 3042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.