Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848854 | 0.82 | RAB9A (0.43) | PTPN1SCDRAB9AMEN1KMT2A | |
| SCHEMBL2848851 | 0.82 | RAB9A (0.43) | PTPN1SCDRAB9AMEN1KMT2A | |
| SCHEMBL3635740 | 0.80 | ATAD2 (0.52) | SCDRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2840566 | 0.75 | NPC1 (0.42) | PTPN1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3637760 | 0.73 | RIPK1 (0.42) | PTPN1SCDRAB9ANPC1MAPT | |
| SCHEMBL2842304 | 0.67 | NPC1 (0.44) | RAB9ANPC1ATAD2MAPTPKM | |
| SCHEMBL2842309 | 0.67 | NPC1 (0.44) | RAB9ANPC1ATAD2MAPTPKM | |
| SCHEMBL2851202 | 0.67 | CSF1R (0.47) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL2851204 | 0.67 | CSF1R (0.47) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL2850067 | 0.66 | USP30 (0.48) | RAB9ANPC1MAPTPKMCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152700-A1 | CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE | Novartis Ag (CH) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008144062-A1 | CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE | NOVARTIS AG (CH) | 2008-11-27 | — | — | WO | disclosed |