Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 7/20 | 0.52 |
| ▸ | MAOA | P21397 | 6/20 | 0.52 |
| ▸ | TLR4 | O00206 | 5/20 | 0.52 |
| ▸ | TLR2 | O60603 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748716 | 0.90 | MAOB (0.63) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL2748717 | 0.90 | MAOB (0.63) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL2748715 | 0.90 | MAOB (0.63) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL5720900 | 0.80 | TLR4 (0.81) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL5720904 | 0.80 | TLR4 (0.81) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL2747523 | 0.79 | FBP1 (0.62) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL2747521 | 0.79 | FBP1 (0.62) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL2747524 | 0.79 | FBP1 (0.62) | FBP1MAOBMAOATLR4TLR2 | |
| SCHEMBL8625071 | 0.79 | FBP1 (0.66) | FBP1TLR4TLR2ALDH1A1KDM4E | |
| SCHEMBL8625069 | 0.79 | FBP1 (0.66) | FBP1TLR4TLR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |